Factor XII - uPAR Upregulate Neutrophil Functions to Influence Wound Healing. The Journal of Clinical Investigation. 2018 128:944-959 Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development. Science Advances. 2018 4: eaat2681.įeatured in: Emory News Release, Science Daily, EurekAlert, Biocompare News The PLAG1-GDH1 axis promotes anoikis resistance and tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer. Molecular Cell. 2018 69:87-99 Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discovery. 2018 8:1438-1457 Critical role of ASCT2-mediated amino acid metabolism in promoting leukemia development and progression. Nature Metabolism. 2019 1:390-403.įeatured in News & Views in Nature Metabolism (2019 1:308–309), Emory News Release, Science Daily, MedicalXpress, EurekAlert Ptpn21 controls hematopoietic stem cell homeostasis and biomechanics. Cell Stem Cell. 2019 24:1-13.įeatured in: Emory News Release, MedicalXpress, Business Standard , Science Daily, Decreased cell stiffness enhances leukemia development and progression. Arginine Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation. JMML tumor cells suppress normal hematopoiesis by disrupting hematopoietic stem cell homeostasis through overproduction of IL-1β. Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation. Interested individuals should send their curriculum vitae and the names and addresses of three references to. Previous experience in cell signaling and experimental hematology is preferable. A variety of experimental approaches, such as mouse genetics, biochemical, and stem cell technologies are undertaken in these studies.Ĭandidates should have a PhD degree with a strong background in molecular biology and cell biology. We are particularly interested in the regulation by protein and lipid phosphatases, including PTPN11, in hematopoietic stem cell biology and in leukemogenesis. Research in our laboratory is centered on the signaling and metabolic mechanisms involved in normal and malignant hematopoiesis. To investigate the molecular mechanisms by which genetic mutations of protein tyrosine phosphatase PTPN11 (SHP2) induce childhood leukemias, and to use this knowledge to develop novel therapeutics for these diseases.
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